Therapeutic activity of multiple common g-chain cytokine inhibition in acute and chronic GVHD
نویسندگان
چکیده
Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany; Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN; Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany; Department of Pathology, Freiburg University Medical Center, Albert-LudwigsUniversity, Freiburg, Germany; and Novartis Institutes for Biomedical Research, Basel, Switzerland
منابع مشابه
Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD.
The common γ chain (CD132) is a subunit of the interleukin (IL) receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Because levels of several of these cytokines were shown to be increased in the serum of patients developing acute and chronic graft-versus-host disease (GVHD), we reasoned that inhibition of CD132 could have a profound effect on GVHD. We observed that anti-CD132 monoclonal ant...
متن کاملTherapeutic activity of multiple common gamma chain cytokine inhibition in acute and chronic GvHD Running title: CD132 INHIBITION REDUCES GVHD
• Monoclonal antibody blockade of the common gamma chain attenuates acute and chronic GvHD. • Common gamma chain cytokines increase granzyme B levels in CD8 T cells, which is reduced upon CD132 blockade in vivo. Abstract The common gamma chain (CD132) is a subunit of the interleukin (IL) receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Because levels of several of these cytokines were sh...
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